Version 01.00, August 16, 1997, Bob Wilson
Please send corrections to Bob Wilson who learned a little French in high school thirty years ago. When unsure of a word or phrase, I enter "(?)" with my best guess. Any help with this translation will be appreciated and credit shared. The source document is OLMIFON.

OLMIFON 300 mg tablets

Introduction in BIAM(?): Feb. 2, 1992
Updated: May 16, 1997

Identification

Form: Compressed powder
Status: commercialized
Pharmacutical Company: LAFON
Product: OLMIFON
History:

Packaging

Package 1

AMM number: 324876-9
40, thermal pressed tablets, PVC/aluminum white

Events(?):

collective agreement(?)
inscription "SS"



Distribution: pharmacy
Status: commercialized
Regulation: list I (?Note: possibly some type of drug classification used in France. I don't know what it corresponds to in the USA.)


Price rules: reembursment of 65%
Price "Pharmacien HT" (wholesale?): 34.70 francs
Retail(?) price: 49.20 francs
TVA(?): 2.10%



Package 2

AMM number: 324875-2
20, thermal pressed tablets, PVC/aluminum white

Events(?):

collective agreement(?) Sept. 9, 1990
inscription "SS" April 14, 1989



Distribution: pharmacy
Status: commercialized
Regulation: list I (?)


Price rules: reembursment of 65%
Price "Pharmacien HT" (wholesale?): 19.09 francs
Retail(?) price: 29.70 francs
TVA(?): 2.10%



Ingredients

Dosage: Per tablet
Active ingredients: Adrafinil, 300 mg.
Inactive ingredients: none

Theraputic Properties

"Psychostimulant and Nootropique (another)" (primary). Bibliography: Class ATC: N06B-X20. Non-aphetamine. Increased wakefullness and alterness.

Theraputic Use

Treatment of symptoms of those having trouble staying alert and depression.

Side Effects

Precautions

Administration

Oral

Dosage Schedules

Usual:
Two to four times per day. One in morning, one at noon; two in morning, one at noon; two in morning, two at noon.

Special conditions:
With poor liver or kidney functions, (?) 300 to 600 mg. per day.

ADRAFINIL

This section is translated from another Web page Adrafinil.

Identification

Assembled identification numbers

CAS: 63547-13-7 DCIR: ADRAFINIL
another number: CRL 40028
invoice(? shipping id?): 2755
rINN: ADRAFINIL

Chemical class

Regulation: list I

Pharmacology

Psychoanalytic

Actions

Primary: Awakening, antonist to alpha 1 adrenergique of the central nervis system. At higher dosage, frees serotonine and dopamine (??).

Research Effects

Psychotonique (??)

Therapeutic Indications

Cerebrial alterness
Treatment of symptoms for those having trouble with alterness and evidence of depression. Double blind studies with a placebo have shown ameleration of psycho-behavior of these subjects.

Side Effects

Animal studies

Dependancy

None

Precautions for Use

Adminstration of dosage

Prescribed for adults: 600 to 1200 mg. per day.
For those with liver or kidney problems: 300 to 600 mg. per day.

Clinic Pharmacology

Bibliography

"Prescrire" 1991. 11: 68-69

Specialist

A special contribution of French knowledge (???): OLMEFON 300 mg. tablets
The following is from a study reported in a Web page article.

Toxicity

The lethal dose for 50% of mice with adrafinil is 800-1000 mg/kg [Rambert et al., 1986]. A 1200 mg. dose, four 300 mg tablets, for a 110 lb. adult would give 24 mg./kg.

For 24 mg./kg.
Weight - tablets(mg)
110 - 4 (1200 mg)
138 - 5 (1500 mg)
165 - 6 (1800 mg)
193 - 7 (2100 mg)
220 - 8 (2400 mg)