Version 01.00, August 16, 1997, Bob Wilson
Please send corrections to Bob Wilson who
learned a little French in high school thirty years ago.
When unsure of a word or phrase, I enter "(?)" with my best guess.
Any help with this translation will be appreciated and credit shared.
The source document is OLMIFON.
OLMIFON 300 mg tablets
Introduction in BIAM(?): Feb. 2, 1992
Updated: May 16, 1997
Form: Compressed powder
Pharmacutical Company: LAFON
- first notice to AAM July 10, 1981
- publication in Journal of AAM Sept. 22, 1981
- marketed Sept. 9, 1985
AMM number: 324876-9
40, thermal pressed tablets, PVC/aluminum white
Regulation: list I (?Note: possibly some type of drug classification used in France. I don't know what it corresponds to in the USA.)
Price rules: reembursment of 65%
Price "Pharmacien HT" (wholesale?): 34.70 francs
Retail(?) price: 49.20 francs
AMM number: 324875-2
20, thermal pressed tablets, PVC/aluminum white
collective agreement(?) Sept. 9, 1990
inscription "SS" April 14, 1989
Regulation: list I (?)
Price rules: reembursment of 65%
Price "Pharmacien HT" (wholesale?): 19.09 francs
Retail(?) price: 29.70 francs
Dosage: Per tablet
Active ingredients: Adrafinil, 300 mg.
Inactive ingredients: none
"Psychostimulant and Nootropique (another)" (primary).
Bibliography: Class ATC: N06B-X20. Non-aphetamine. Increased wakefullness and alterness.
Treatment of symptoms of those having trouble staying alert and
- Agitation - transitory. Regresses spontaneously with continued treatment at the same or reduced dosage.
- Confusion - tansitory. Regresses spontaneously with continued treatment at the same or reduced dosage.
- Agressiveness - transitory. Regresses spontaneously with continued treatment at the same or reduced dosage.
- Excitable - transitory. Regresses spontaneously with continued treatment at the same or reduced dosage.
- Mood reversal - rare. Check for manic-depression.
- Stomach ache
- Skin outbreak (?rash, hives?)
- Watch For - During the usage of Olmifon, do not fail to verify the effects of it on the patient (?paraphrased).
- Epilepsy - Make sure the treatment with anti-convulsants is effective and correct with the prescription of Olmifon.
- Poor liver function - Use a dosage no more than 300 to 600 mg. per day.
- Poor kidney fuction - Use a dosage no more than 300 to 600 mg. per day.
- Prolonged treatment - Watch for "Phasphatease Alcalines" (??)
Two to four times per day. One in morning, one at noon; two in morning, one at noon; two in morning, two at noon.
With poor liver or kidney functions, (?) 300 to 600 mg. per day.
This section is translated from another Web page
Assembled identification numbers
CAS: 63547-13-7 DCIR: ADRAFINIL
another number: CRL 40028
invoice(? shipping id?): 2755
Regulation: list I
Primary: Awakening, antonist to alpha 1 adrenergique of the central nervis system. At higher dosage, frees serotonine and dopamine (??).
Treatment of symptoms for those having trouble with alterness and evidence of depression.
Double blind studies with a placebo have shown ameleration of psycho-behavior of these subjects.
- Skin eruptions (?rash, hives, acme?) - very rare
- Upset stomach - very rare
- Agitation - rare
- Confusion - very rare
- Mood reversal - very rare. Associated with manic-depressive disorder.
- Phosphate "Alcalines(augmentation)" - very rare. Prolonged use
- Not "TERATOGENE" with animals: Studies made with rats and rabbits.
- Information missing for human species
Precautions for Use
- Insufficient liver function
- Cirrosis - increased action of the bioactives with cirrosis patients.
- Insufficient kidney fuction - pharmacology studies show an increase in half-life due to elimination of metabotic by products
- Journals - Interdict substance: Journal Offical October 21, 1994.
Adminstration of dosage
Prescribed for adults: 600 to 1200 mg. per day.
For those with liver or kidney problems: 300 to 600 mg. per day.
- Half-life, 1 hour
- Elimination via kidney
- Absorbion - Maximum plasma concentration one hour after an oral doage.
- "Repartition"?> - Connection (?binding?) with plasma protiens is 65% (?no idea of what this is?).
- Half-life - one hour
- Metabolized - Metabolized by the liver with 65% into a derived acid and "GLYCUROCONJUGUE".
- Elimination - (Renal) by elimination of the "GLYCUROCONJUGUE".
"Prescrire" 1991. 11: 68-69
A special contribution of French knowledge (???): OLMEFON 300 mg. tablets
The following is from a study reported in
a Web page article.
The lethal dose for 50% of mice with adrafinil is 800-1000 mg/kg [Rambert et al., 1986]. A 1200 mg. dose, four 300 mg tablets, for a 110 lb. adult would give 24 mg./kg.
For 24 mg./kg.
Weight - tablets(mg)
110 - 4 (1200 mg)
138 - 5 (1500 mg)
165 - 6 (1800 mg)
193 - 7 (2100 mg)
220 - 8 (2400 mg)